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- Some ligands can reduce the efficacy but increase the affinity of the orthosteric agonist for the receptor. Whereas antagonists have no preference in their affinity for a receptor state. InLangley challenged the dominant hypothesis that drugs act at nerve endings by demonstrating that nicotine acted at sympathetic ganglia even after the degeneration of the severed preganglionic nerve endings.
Receptor theory is the application of receptor models to explain drug behavior. A J Clark was the first to quantify drug-induced biological responses using an equation described f-mediated receptor activation. So far, nearly all of the quantitative theoretical modelling of receptor function has centred on ligand-gated ion channels and GPCRs. In , Langley challenged the dominant hypothesis that drugs act at nerve endings by demonstrating that nicotine acted at sympathetic ganglia even after the degeneration of the severed preganglionic nerve endings.
It also postulated that these receptive substances were different in different species citing the fact that nicotine-induced muscle paralysis in mammals was absent in crayfish. However, he later modified the theory in order to explain immune reactions and the selectivity of the immune response. sjokoladefondant melkesjokolade
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